Chen, Jianyong
6 files · 1.5 GB · gzip
hybrid · semantic + lexical · 393 datasets ranked · 3.96s
Chen, Jianyong
6 files · 1.5 GB · gzip
A first sequence of the Ae. speltoides B chromosome has been available since 2020 (RUBAN et al. 2020b), but this assembly represents ~16% of the B only and thus cannot be used to uncover B-encoded genes. Now, high-molecular-weight DNA from +B leaf tissue of the clonally propagated +B plant was used to generate a chromosome-scale genome assembly. A total of 154 Gb of PacBio HiFi reads and 36.4 Gb of Nanopore reads (>25 kb) were generated for primary assembly using hifiasm (Cheng et al. 2026). The resulting 5.47 Gb assembly achieved 93.7% BUSCO completeness (contig N50 = 17.1 Mb). Approximately 104 Gb of Hi-C sequencing data derived from leaf tissue of the same +B plant were employed to scaffold the primary contigs. The assembly yielded eight large scaffolds (398-835 Mb), each displaying a characteristic Rabl configuration. Alignment of these scaffolds to the reference genome of Ae. speltoides accession AEG-9674-1 without B chromosome (Avni et al. 2022) revealed that seven of the eight scaffolds showed strong synteny with the standard A chromosomes 1S-7S. To determine whether the remaining large scaffold corresponded to the B chromosome, we generated ~60 Gb of whole-genome sequencing (WGS) data from 0B AR-derived lateral root tissue of the same plant, as well as approximately 36 Gb of WGS data from +B leaf tissue. Comparative read-mapping analyses showed that the eighth scaffold exhibited normal sequencing coverage in +B leaf-derived data but substantially reduced coverage in 0B AR-derived data. Thus, the 398 Mb scaffold represents the B chromosome, accounting for 69% of its size as estimated by flow cytometry. Additionally, 4.81 Gb of contigs were assigned to the seven pairs of A chromosomes, representing 91% of their estimated size (1C=5.27 Gb). Consequently, we produced a high-quality chromosome-scale assembly of Ae. speltoides carrying B chromosomes. To identify genes associated with the B chromosome elimination process, RNA-seq was performed across developmental stages and different tissues in which B chromosome behavior differs. Using all +B RNA-seq datasets, we annotated the Ae. speltoides genome assembly containing the B chromosome. This annotation identified 59,981 transcripts and 47792 protein-coding genes on the seven A chromosomes and 5,940 transcripts and 4,196 protein-coding genes on the B chromosome.
Madhusudan, Gujral
6 files · 29 MB · parquetdeclared
Large language models (LLMs) are trained on massive, publicly available text datasets comprising trillions of tokens, enabling them to excel at general language tasks like next-token prediction. However, LLMs often struggle with domain-specific prompts, exhibiting reduced accuracy or generating inaccurate information (hallucinations). This is because they lack sufficient subject matter expertise. Two primary approaches exist to address this limitation for augmenting LLMs knowledge: Retrieval-Augmented Generation (RAG) and fine-tuning. This presentation focuses on fine-tuning smaller LLMs with domain-specific instruct datasets using the LoRA (Low-Rank Adaptation) technique on Gaudi hardware. We will leverage publicly available LLMs and datasets from the Hugging Face Hub for this demonstration. Though it is possible to fine tune LLMs with plain text data - sourced from documents, articles, and other materials.
Azziz, Ricardo
1 files · 1.6 MB · docxdeclared
Supplemental Table 1. Meeting Agenda of the 2024 PCOS Challenge-CDC Stakeholder Meeting on Testosterone Reference Interval Standardization. August 26, 2024. Centers for Disease Control and Prevention, Atlanta, Georgia. Supplemental Table 2. Proposed Four-Stage Workflow for Developing Standardized Testosterone Reference Intervals Using Existing Study Data.
Lopez-Gomez, Ignacio
2 files · 45 GB · gzipdeclared
Trained GenFocal model checkpoints. This record contains checkpoints for GenFocal: Checkpoints for the Diffusion-based Super-Resolution model (~8.15 GiB) CHeckpoints for the Flow Matching Debiasing model (~36.45 GiB)
García Mina, Janeth Elizabeth · Rodríguez Garófalo, Napoleón Hernán · Rumbaut-Rangel, Dayron · et al.
6 files · 737 KB · docx, pdfdeclared
El objetivo de este estudio es evaluar la importancia de la inteligencia artificial (IA) en el proceso de formación académica de estudiantes de educación básica, específicamente en la enseñanza de ciencias naturales. La investigación destaca cómo la IA puede personalizar el aprendizaje, adaptándose a los estilos individuales de cada alumno, lo que resulta en una experiencia educativa más efectiva y significativa. Se utilizó un diseño cuasiexperimental con una muestra de 60 estudiantes de sexto año, distribuidos en un grupo control (30 estudiantes) que recibió instrucción tradicional y un grupo experimental (30 estudiantes) que utilizó herramientas de IA, como chatbots educativos y plataformas de aprendizaje adaptativo. Los resultados mostraron que el 70% de los estudiantes del grupo experimental alcanzaron calificaciones superiores a 8, en comparación con solo el 30% del grupo control. Este hallazgo sugiere que la implementación de herramientas de IA puede transformar la educación básica, mejorando tanto el rendimiento académico como la motivación de los estudiantes. En conclusión, el estudio resalta la necesidad de seguir investigando y desarrollando nuevas estrategias educativas que integren la IA para maximizar su potencial en la educación.
Makhado, Langanani Christinah · Raliphaswa, Ndidzulafhi Selina
9 files · 157 KB · docxdeclared
This dataset contains anonymized transcripts derived from face-to-face interviews conducted with pregnant women and breastfeeding mothers as part of the research study. The interviews were audio-recorded and transcribed verbatim to capture participants' experiences, perceptions, and insights related to the study topic. All personally identifiable information has been removed to protect participant confidentiality. The transcripts are provided to support transparency, reproducibility, and further research related to the findings reported in the associated article
Bakare, Akeem
1 files · 34 KB · gzipdeclared
Contig-ARG-Linkage Reproducible Snakemake pipeline that links antibiotic resistance genes to bacterial hosts in metagenomic data. For each sample, it assembles reads (MEGAHIT), detects ARGs (BLASTn vs MEGARes), classifies contigs (Kraken2), and joins by contig ID. Pinned envs, checksummed databases, container builds, and CI-tested on synthetic data.
Stein, Samuel
5 files · 139 MB · gzipdeclared
Raw experimental dataset accompanying the paper "Calibration-Conditioned FiLM Decoders for Low-Latency Decoding of Quantum Error Correction Evaluated on IBM Repetition-Code Experiments." This dataset contains repetition-code experiments executed on three IBM Quantum processors -- ibm_kingston, ibm_pittsburgh, and ibm_fez. It comprises 352 hardware snapshots spanning code distances d = 3, 5, 7, 9, 11, syndrome-round counts r = 1 to 11, and both the X and Z logical bases. Each snapshot runs several repetition-code chains in parallel and carries the device calibration data captured at execution time, totalling several million measurement shots. All data is provided raw, exactly as returned by the hardware -- no machine-learning processing or sparsification is applied -- and is anonymized (no IBM Runtime job identifiers are released). CONTENTS - ibm_kingston.tar.gz, ibm_pittsburgh.tar.gz, ibm_fez.tar.gz per-device archives, each unpacking to <device>/d<D>_r<R>/job_<n>/ - index.csv one row per snapshot: path, backend, d, rounds, basis, logical_states, n_chains, shots - README.md full description of the layout and field definitions Each job_<n>/ directory contains: - info.json experiment parameters (device, d, rounds, basis, states, shots, n_chains) - calibration.json the device calibration snapshot at execution time (T1, T2, gate and readout error rates, coupling map) - circuit_state0.qasm, circuit_state1.qasm transpiled circuits as executed - bitstrings.json raw per-shot measurement records for every parallel chain USAGE Because each snapshot stores its own calibration data, the per-device and per-(d, r, basis) structure used in the paper is recoverable by filtering index.csv. The same calibration is consumed by both the FiLM decoder (via its calibration-graph encoder) and the modified MWPM baseline (via its detector-graph edge weights). Github to be updated for corresponding experiments on approval. Please contact Samuel Stein (samuel.stein@pnnl.gov) if you need any information or source docs before hand.
Fontelo, Paul
1 files · 26 KB · docxdeclared
Auto-Brewery Syndrome (ABS), also known as gut fermentation syndrome, is a condition in which microbial fermentation of dietary carbohydrates generates endogenous ethanol, causing signs and symptoms of alcohol intoxication without alcohol consumption. Misdiagnosis as alcohol use disorder (AUD) is common and carries severe medical, psychosocial, legal, and forensic consequences. The objective of thus narrative review is to synthesize the clinical literature on ABS for practicing clinicians and to present the first systematic analysis of ABS susceptibility in Asian populations - including communities of Asian descent in Western countries.
Hackl, Jürgen
6 files · 132 MB · parquet, tiffdeclared
EuroFlood is an open, cloud-native index over the JRC/Copernicus CEMS-EFAS Satellite-Derived Flood Depth Maps for Europe (Betterle & Salamon, 2025; CC-BY-4.0) - ~3,280 satellite-derived observed flood-depth maps across Europe, 2015-2024. The bundle is a sparse Cloud-Optimized GeoTIFF encoding, per pixel, the set of flood events that inundated it, plus a combo_id -sorted GeoParquet dictionary and a small events table. Query by region and time via HTTP range reads (GDAL /vsicurl + DuckDB) to retrieve matching events, then fetch only the source depth rasters needed. Built with the open-source EuroFlood Python package ( pip install euroflood ).
Bojarski, Krzysztof Kamil
1 files · 66 MB · gzipdeclared
This repository contains structural models and molecular dynamics input files for complexes of cathepsins B, S, and K with three glycosaminoglycan-like ligands: naphthalene-1,3,6-trisulfonate (NTS), amide-linked bis(naphthalene disulfonate) (BNS), and suramin. Initial protein and ligand structures used for molecular docking are provided in AutoDock3 format. For each cathepsin-ligand complex, the three most populated docking clusters are included, with three representative binding poses per cluster. The repository further contains system topologies and initial coordinates for molecular dynamics simulations in AMBER format ( .parm7 and .rst7 ), ligand library files required for tleap, molecular dynamics input files, and scripts used for post-processing and analysis of the MD trajectories.
Chander, Aishwarya
2 files · 8.7 GB · gzip, zipdeclared
Analysis code and processed data for the manuscript: "Multiple myeloma and therapy reshape the bone marrow niche to durably constrain immune reconstitution and vaccine responsiveness." This repository accompanies a longitudinal multi-omic study of immune dysfunction in multiple myeloma (MM). Matched bone marrow and peripheral blood from MM patients were profiled across diagnosis, induction, autologous stem cell transplant (ASCT), and recovery, together with matched healthy donors and vaccine response subcohorts. The analyses show that the tumor imposes a compartment specific immune program; marrow-restricted metabolic, inflammatory, and cytotoxic-effector changes not mirrored in blood; and, that adaptive immune reconstitution remains impaired up to two years post-ASCT. Half of patients failed to mount IgG responses to a high dose nonadjuvanted influenza vaccine, a defect overcome by the LNP adjuvanted COVID mRNA vaccine. Contents: Single cell RNA-seq (BMMC and PBMC), flow cytometry, Olink proteomics, and MSD cytokine analysis pipelines, plus the notebooks generating all manuscript figures. Processed/derived data needed to reproduce the figures are included; raw sequencing data are deposited in GEO.
Amilon, Jesper
1 files · 38 KB · gzipdeclared
Version 1.0 of VerNFR, a Frama-C plugin for verifying non-functional requirements of C code and interface contracts. Release to accompany submission to ISoLA2026 See the Readme for further details and instructions.
Walsh, Calum · Srinivas, Meghana · Stinear, Timothy · et al.
100 files · 2.7 GB · gzip, tsvdeclared
GROND (Genome-derived Ribosomal OperoN Database) A quality-checked and publicly-available database of 16S-ITS-23S RRNA operon sequences and their constituent 16S and 23S genes. Based on GTDB release R232.
Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services
2 files · 1.5 MB · docx, pdfdeclared
This is the report on the indigenous and local knowledge (ILK) dialogue workshop for the first order draft of the summary for policymakers and the second order draft of the IPBES assessment of the sustainable use of wild species (the "sustainable use assessment"). It was held from 17-21 May 2021, online, due to the ongoing COVID-19 pandemic. The report aims to provide a written record of the dialogue workshop, which can be used by assessment authors to inform their work on the sustainable use assessment, and also by all dialogue participants who may wish to review and contribute to the work of the assessment moving forward. The report is not intended to be comprehensive or give final resolution to the many interesting discussions and debates that took place during the workshop. Instead, it is intended as a written record of the discussions, and this conversation will continue to evolve in the course of the assessment process. For this reason, clear points of agreement are discussed, but diverging views among participants are also presented for further attention and discussion.
Ogah, Odey
4 files · 3.4 MB · docx, pdf, zipdeclared
The study investigated the determinants of the migration of youth in Benue State from agricultural activities using a multi stage survey research design. The population of the study comprised 90 households in the three zones in Benue state selected by simple random sampling. A sampling proportion of 5% was used and a sample size of 270 was drawn. The instrument for data collection was a self-developed questionnaire. Data collected was analysed using frequencies distribution, mean, standard deviation and probit regression to achieve the research objectives while chi square goodness of fit was used to test the hypothesis. The findings revealed that 69.0% of the youth involved in agricultural activities in the study area were within the ages of 26- 30 years old while few (7.7%) are of 31years and above. The findings of the study revealed that land tenure practices have high influence on agricultural land developmental activities of youth in the study area. The study found that there is a plethora of factors responsible for seasonal migration of youth in the study area and these includes; Lack of access to modern farming equipment and technology; limited economic opportunities in the agricultural sector. The study concludes that youth migration affects agricultural activities in the study area. The study therefore recommended among others, skills diversification programme that will equip youth in diverse skills beyond seasonal agricultural works that could be utilised all year round. Year round employment opportunities that would provide consistent employment for the youth, education and training initiatives that would focus on agricultural techniques and sustainable practices, access to financial resources and collaboration and networking between local governments, NGOS, and the private sectors.
Duru, Dr. Eramus Ejike · Chukwudebe, Prof. Gloria · Ndubuisi, Okereke
4 files · 3.3 MB · docx, pdf, zipdeclared
This study mainly aimed to examine the adoption of e-procurement and its impact on public sector efficiency in Ministries, Departments, and Agencies (MDAs) in Southeastern Nigeria. The study adopted a mixed-method research design, combining quantitative and qualitative approaches. Data were collected from procurement officers, ICT personnel, administrative heads, and senior staff of MDAs across the five Southeastern Nigerian States (Abia, Anambra, Ebonyi, Enugu, and Imo), 60 persons out of the 80 targeted responded to questionnaires. Quantitative data were analysed using descriptive and inferential statistical tools employed were multiple regression, while qualitative data were thematically analysed to enrich the findings. Multiple Linear regression Analysis was used the relationship between the efficiency of procurement and its different methods on the public sector of MDAs in South-East region of Nigeria. The findings of the results revealed that E-payment, E-request, E-Tendering had a positive relationship with the efficiency of procurement whereas E-bidding has negative relationship with the efficiency of procurement. Also, the results revealed that E-payment and E-Tendering had a significant impact on the procurement at 5% level of significance (p-values of 0.0000 and 0.0001, respectively) whereas E-request, E-tendering and E-bidding does not influence the efficiency of procurement. An R-squared of 82% indicates that 82% of the total variation in the efficiency of procurement method is accounted for by variations in E-payment, E-request, E-tendering and E-bidding; whereas about 18% of the variation in efficiency of procurement method could be attributed to variables not included in the study. Thus, the study recommended that increased investment in ICT infrastructure, continuous training of procurement personnel, strong political and managerial commitment, and the strengthening of regulatory frameworks to ensure the successful institutionalization of e-procurement across MDAs in Southeastern Nigeria.
Chirwa, Frank B. · Mukuka, Christopher Kabwe
4 files · 2.0 MB · docx, pdf, zipdeclared
rd of the world church. The continued use of Western interpretive paradigms has systematically marginalized African oral resources, proverbs, storytelling and community-based wisdom creating a missiological vacuum. This cultural dissonance creates scholarly conflict, restricts church growth and drives members to Pentecostal and African Initiated Churches that address existential concerns (witchcraft, sickness, ancestral beliefs) through their own presumed stylistic biblical interpretations. This qualitative theoretical synthesis draws on postcolonial theory of hybridities (Homi K. Bhabha), a comparative exegesis of Romans 13:1-17 and John 4:1-42, and a systematic review of the African biblical hermeneutics literature. Three dynamics of hybridity are used as analytical tools to mediate between Western and African poles of interpretation: calculated negotiation, prudent affiliation and idealized memory. The tension between the Western historical-grammatical methods and legitimate African contextual concerns is still unresolved and hermeneutical conflicts among Adventist scholars continue. Pentecostal movements address existential questions (witchcraft, sickness, ancestor mediation) with culturally resonant symbols, filling a void mainstream Adventism has left open. A hybridized hermeneutic working in Bhabha's "Third Space" reconciles Western interpretive norms with African oral traditions without compromising Adventist orthodoxy. Indeed, the dynamics of hybridity which African Adventist hermeneutics calls for are exemplified precisely in Jesus' encounter with the Samaritan woman (John 4) and Paul's strategy in Romans 13. This study offers a constructive and biblical faithful framework for African Adventist hermeneutics. This hybrid approach to reclaiming indigenous interpretive heritage, while critical of global Adventist norms, minimizes interpretive discord, challenges manipulative practices, and promotes authentic church growth in Africa. "Christ's method alone will bring true success in reaching the people," said Ellen G. White (1905, p. 143).
Correia, Antonia · Príncipe, Pedro
2 files · 333 KB · docx, pdfdeclared
All this resource materials were developed and piloted as part of the PATTERN project ( https://www.pattern-openresearch.eu/ ). With this support materials trainers will find all the resources to deliver a 2h face-to-face or adapt to a webinar session on Empowering researchers: retaining copyright and maximizing your impact in Open Access Publishing , available in OpenPlato - https://openplato.eu/course/view.php?id=134 Here you will find guidelines, session plans, materials for each activity, and participants' evaluations so that you can carry out the course yourself. Training goals By the end of this course, the learners should be able to: Know about authors and publisher rights, define copyright agreement limits; Amend a copyright agreement. Choose appropriate Licences as well as differentiate level of access rights and state types of licences. Retain copyright to a publication and apply Green OA to your discipline/project/workflow. Course structure The course will cover the following topics: Introduction to Copyright and Open Access: Overview of copyright basics and the global landscape of open access. Rights Retention Strategy (RRS): Detailed sessions on RRS, including practical exercises using templates and real-world scenarios. Publishing Routes and Their Implications: Exploration of various publishing models and their impacts on authors' rights and obligations. Workshops and Hands-on Training: Practical application through case studies, role-playing, and problem-solving exercises related to copyright and publishing. Learning outcomes The learners will gain tools to: Effectively retain copyright: Understand and implement Rights Retention Strategies to maintain control over their own published works, ensuring they can meet funder requirements for open access. Navigate various publishing landscapes: Identify and choose between Gold, Hybrid, and Diamond Open Access avenues, and understand the implications of each on their rights and academic visibility. Utilize legal resources to safeguard rights: Apply tools such as the Creative Commons licenses and template letters to negotiate and secure their rights during the publication process. Advocate for open access policies: Leverage their knowledge to influence institutional and publisher policies toward more open and equitable sharing of knowledge. Files overview Materials OAroutes_graphic_Pattern_EN_v2_20260130_Diamond (png) OAroutes_graphic_Pattern_EN_v2_20260130_Dourado (png) OAroutes_graphic_Pattern_EN_v2_20260130_Hybrid (png) OAroutes_graphic_Pattern_EN_v2_20260130_Preprint (png) OAroutes_graphic_Pattern_EN_v2_20260130_RRS_complete (png) OAroutes_graphic_Pattern_EN_v2_20260130_Subscription (png) OA_RightsRetention_Session_Planning (docx, pdf) Slides EmpoweringResearchers_RRS_Face2face(pptx) EmpoweringResearchers_RRS_Webinar (pptx) Session Plan OA_RightsRetention_Session_Plan_EN.docx OA_RightsRetention_Session_Plan_EN.pdf
Rayyanu, Dalhatu · (Ph.D), Abubakar Salihu Oloko · (Ph.D), Jerry James Doka · et al.
4 files · 3.9 MB · docx, pdf, zipdeclared
This study examined the influence of self-efficacy and family dynamics on cyberbullying among students of Federal Polytechnic Nasarawa, Nasarawa State, Nigeria. Employing a descriptive survey design, data were collected from a sample of 334 students, with 298 valid responses comprising 213 (71.5%) males and 85 (28.5%) females. The age distribution included 17–22 years (45.6%), 23–30 years (36.6%), and 31 years and above (17.8%), while marital status showed 219 (73.5%) single and 79 (26.5%) married. Educational status indicated 185 (62.1%) HND students and 113 (37.9%) ND students, with family types including nuclear (70.8%), extended (23.2%), and single-parent (6.0%). Participants were drawn using simple random sampling from the Federal Polytechnic Nasarawa. The instruments used included the Questionnaire of Systemic Family Dynamics (SSFD), General Self-Efficacy Scale (GSE), and Revised Cyberbullying Behaviour Questionnaire (CBQ), all demonstrating acceptable reliability coefficients. Three hypotheses were tested using multiple regression analysis at a 0.05 level of significance. Results revealed that family dynamics subscale collectively predicted cyberbullying (R = .532, R² = .210, F(4, 294) = 15.930, p < .001), though individual subscales were not significant. Self-efficacy also significantly influenced cyberbullying (R = .369, R² = .136, F(3, 322) = 16.882, p < .001), with cohesion as the key predictor (β = .246, t = 2.742, p = .023). Jointly, self-efficacy and family dynamics accounted for 49% of the variance in cyberbullying (R = .332, R² = .490, F(2, 296) = 10.930, p < .001), but independently, neither was significant. Based on these findings, it is recommended that school management, in collaboration with psychologists, should provide accessible counseling services that address dysfunctional family dynamics, offering tools for conflict resolution and emotional support to prevent escalation into cyber aggression.